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Spring 2021

MAIT cells are imprinted by the microbiota in early life and promote tissue repair. Multiplexed laser particles for spatially resolved single-cell analysis. Optical Pooled Screens in Human Cells.

Monosynaptic tracing maps brain-wide afferent oligodendrocyte precursor cell connectivity. Regulation of lifespan by neural excitation and REST.

Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics. Population imaging of neural activity in awake behaving mice.

Creating a neuroprosthesis for active tactile exploration of textures. Ventricular arrhythmia risk prediction in repaired Tetralogy of Fallot using personalized computational cardiac models.

Highly structured homolog pairing reflects functional organization of the Drosophila genome. In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles.

Inverse probability weighted estimation of risk under representative interventions in observational studies. Generational Biodegradable and Regenerative Polyphosphazene Polymers and their Blends with Poly lactic-co-glycolic acid. A nanoelectrode array for obtaining intracellular recordings from thousands of connected neurons. Electrical and synaptic integration of glioma into neural circuits. Epigenome editing strategies for the functional annotation of CTCF insulators. Genetic voltage indicators.

Computational chemoproteomics to understand the role of selected psychoactives in treating mental health indications. Surface association sensitizes Pseudomonas aeruginosa to quorum sensing. T cells limits tonic signaling associated with chimeric antigen receptors. Supervised classification enables rapid annotation of cell atlases. Gasdermin D activity in inflammation and host defense.

Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice. Towards objective definition of psychopathology in post-traumatic stress disorder.

A pooled single-cell genetic screen identifies regulatory checkpoints in the continuum of the epithelial-to-mesenchymal transition. Precision electronic medicine in the brain. Diffuse intrinsic pontine glioma: molecular landscape and emerging therapeutic targets. Emotion words, emotion concepts, and emotional development in children: A constructionist hypothesis.

Monitoring gasdermin pore formation in vitro. Predictive shifts in free energy couple mutations to their phenotypic consequences. Emerging mechanistic underpinnings and therapeutic targets for chemotherapy-related cognitive impairment. High-resolution, high-contrast mid-infrared imaging of fresh biological samples with ultraviolet-localized photoacoustic microscopy. Suppression of transcytosis regulates zebrafish blood-brain barrier function. Neural circuitry of social learning in Drosophila requires multiple inputs to facilitate inter-species communication.

Computationally guided personalized targeted ablation of persistent atrial fibrillation. Bringing Microscopy-By-Sequencing into View. Neuropeptide F regulates courtship in Drosophila through a male-specific neuronal circuit. Nicotinamide adenine dinucleotides and their precursor NMN have no direct effect on microtubule dynamics in purified brain tubulin. Variability in nicotine conditioned place preference and stress-induced reinstatement in mice: Effects of sex, initial chamber preference, and guanfacine.

Transforming the development and dissemination of cutting-edge microscopy and computation. On the analysis of two-phase designs in cluster-correlated data settings. Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets. Resolving medulloblastoma cellular architecture by single-cell genomics.

Advances in the automation of whole-cell patch clamp technology. A cytosine deaminase for programmable single-base RNA editing. Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8.

The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology. Transgeneratonal inheritance of ethanol preference is caused by maternal NPF repression. A comprehensive, multiscale framework for evaluation of arrhythmias arising from cell therapy in the whole post-myocardial infarcted heart. PKR activation by noncanonical ligands: a 5'-triphosphate requirement versus antisense contamination.

Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice. Post-Transcriptional Noise Control. Simultaneous motor preparation and execution in a last-moment reach correction task. Quantitative evidence for early metastatic seeding in colorectal cancer.

Divergence in the functional organization of human and macaque auditory cortex revealed by fMRI responses to harmonic tones.

Mediate Transgenerational Learned Pathogenic Avoidance. Single cell expression analysis reveals anatomical and cell cycle-dependent transcriptional shifts during heart development. Structural and mechanistic elucidation of inflammasome signaling by cryo-EM. Quantitative in vivo imaging of neuronal glucose concentrations with a genetically encoded fluorescence lifetime sensor. Measuring shared responses across subjects using intersubject correlation.

Conscious awareness is necessary for affective faces to influence social judgments. The ancestral and industrialized gut microbiota and implications for human health. Islands of retroelements are major components of Drosophila centromeres. Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1.

Light-sheet microscopy in the near-infrared II window. Light-based control of metabolic flux through assembly of synthetic organelles.

Microfluidic-based transcriptomics reveal force-independent bacterial rheosensing. Synthetic biology strategies for microbial biosynthesis of plant natural products. Structural, interpersonal, psychosocial, and behavioral risk factors for HIV acquisition among female bar workers in Dar es Salaam, Tanzania. Representational similarity precedes category selectivity in the developing ventral visual pathway.

NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity. Human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis.

Nicotinamide mononucleotide NMN supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Deep convolutional models improve predictions of macaque V1 responses to natural images. Frailty biomarkers in humans and rodents: Current approaches and future advances. Cytokine Circuits in Cardiovascular Disease. Nanowired Bioelectric Interfaces. Arrhythmogenic propensity of the fibrotic substrate after atrial fibrillation ablation: a longitudinal study using magnetic resonance imaging-based atrial models.

Small molecule targeting of RNA structures in neurological disorders. In vivo superresolution photoacoustic computed tomography by localization of single dyed droplets. The emergent landscape of the mouse gut endoderm at single-cell resolution. Does Autophagy Promote Longevity? It Depends. CD22 blockade restores homeostatic microglial phagocytosis in ageing brains.

Oxytocin-dependent reopening of a social reward learning critical period with MDMA. An orange calcium-modulated bioluminescent indicator for non-invasive activity imaging. High-throughput, label-free, single-cell photoacoustic microscopy of intratumoral metabolic heterogeneity.

Association of regional myocardial conduction velocity with the distribution of hypoattenuation on contrast-enhanced perfusion computed tomography in patients with postinfarct ventricular tachycardia. Precise small-molecule cleavage of an r CUG repeat expansion in a myotonic dystrophy mouse model. A theoretical analysis of single molecule protein sequencing via weak binding spectra.

Prometheus Unbound in Ya p Heart. Genomic Medicine-Progress, Pitfalls, and Promise. Characterization of cell fate probabilities in single-cell data with Palantir. Multigenerational obesity-induced perturbations in oocyte-secreted factor signalling can be ameliorated by exercise and nicotinamide mononucleotide.

How face perception unfolds over time. Studying interactions between dendritic cells and T cells in vivo. Lymphatic network remodeling after small bowel resection. Advances in high-speed atomic force microscopy HS-AFM reveal dynamics of transmembrane channels and transporters. Neural mechanisms of social homeostasis.

Brain maps at the nanoscale. High-throughput screening and classification of chemicals and their effects on neuronal gene expression using RASL-seq. Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups.

Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses. A novel dopamine D1 receptor agonist excites delay-dependent working memory-related neuronal firing in primate dorsolateral prefrontal cortex. Multiple basal cell carcinomas in a patient with myotonic dystrophy type 1. Personalized virtual-heart technology for guiding the ablation of infarct-related ventricular tachycardia. Developmental origins and emerging therapeutic opportunities for childhood cancer.

Single-shot real-time femtosecond imaging of temporal focusing. Spastin is a dual-function enzyme that severs microtubules and promotes their regrowth to increase the number and mass of microtubules. Augmented pseudo-likelihood estimation for two-phase studies. Novel electrode technologies for neural recordings. An integrative computational architecture for object-driven cortex.

Epigenetic changes during aging and their reprogramming potential. Single-shot ultrafast optical imaging. Dichroism-sensitive photoacoustic computed tomography. Nepal Pioneer Worksite Intervention Study to lower cardio-metabolic risk factors: design and protocol. Bioinspired neuron-like electronics. Phosphate graphene as an intrinsically osteoinductive scaffold for stem cell-driven bone regeneration.

The single-cell transcriptional landscape of mammalian organogenesis. Photoacoustic computed tomography of human extremities. Genomic evidence for shared common ancestry of East African hunting-gathering populations and insights into local adaptation.

Combinatorial Control through Allostery. A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP. The role of personalized atrial modeling in understanding atrial fibrillation mechanisms and improving treatment.

L1 drives IFN in senescent cells and promotes age-associated inflammation. Spiegelman and Zhou Respond. Differential regulation of the Drosophila sleep homeostat by circadian and arousal inputs. Mapping DNA sequence to transcription factor binding energy in vivo.

Transcytosis at the blood-brain barrier. Intersectional monosynaptic tracing for dissecting subtype-specific organization of GABAergic interneuron inputs.

Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 IRAK4. New insights on the cardiac safety factor: Unraveling the relationship between conduction velocity and robustness of propagation. Molecular mechanism for NLRP6 inflammasome assembly and activation.

Mimicry by a viral RHIM. Population structure of human gut bacteria in a diverse cohort from rural Tanzania and Botswana. Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution. Discovery of a ZIP7 inhibitor from a Notch pathway screen. Intensiometric biosensors visualize the activity of multiple small GTPases in vivo.

Single-cell transcriptomic analysis of mouse neocortical development. The usual suspects, dopamine and alpha-synuclein, conspire to cause neurodegeneration. Words are a context for mental inference. Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex.

A likelihood approach to testing hypotheses on the co-evolution of epigenome and genome. A compressed sensing framework for efficient dissection of neural circuits. Imaging whole nervous systems: insights into behavior from worms to fish. Expansion microscopy: principles and uses in biological research. From genetics to smart watches: developments in precision cardiology. Protein engineering strategies for improving the selective methylation of target CpG sites by a dCas9-directed cytosine methyltransferase in bacteria.

A liquid-like organelle at the root of motile ciliopathy. Transcriptional profiling of isogenic Friedreich ataxia neurons and effect of an HDAC inhibitor on disease signatures. Neuronal photoactivation through second-harmonic near-infrared absorption by gold nanoparticles. Rapamycin-inspired macrocycles with new target specificity. Transvaginal fast-scanning optical-resolution photoacoustic endoscopy. In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra.

There is no impact of exposure measurement error on latency estimation in linear models. Dopamine tunes prefrontal outputs to orchestrate aversive processing. Choice of vehicle affects pyraclostrobin toxicity in mice. Correction: Drosophila species learn dialects through communal living.

Big bottlenecks in cardiovascular tissue engineering. Leveraging calcium imaging to illuminate circuit dysfunction in addiction. Structures and gating mechanism of human TRPM2. Synthetic Bessel light needle for extended depth-of-field microscopy.

A whole lifespan mouse multi-tissue DNA methylation clock. HumanNet v2: human gene networks for disease research. Virtual electrophysiological study as a tool for evaluating efficacy of MRI techniques in predicting adverse arrhythmic events in ischemic patients. Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli. Publisher Correction: Longitudinal analysis of biomarker data from a personalized nutrition platform in healthy subjects.

Brain-machine interface cursor position only weakly affects monkey and human motor cortical activity in the absence of arm movements. Drugging the RNA World. Learning time-varying information flow from single-cell epithelial to mesenchymal transition data. Computational models in cardiology. Pathogen blockade of TAK1 triggers caspasedependent cleavage of gasdermin D and cell death.

PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex. Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia. Neural Circuit Motifs in Valence Processing. Lymph nodes go with the flow. An integrative tissue-network approach to identify and test human disease genes. Highly parallel single-molecule identification of proteins in zeptomole-scale mixtures. Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells.

The Promise and Challenge of Digital Biology. Biomaterial microlasers implantable in the cornea, skin, and blood. Caenorhabditis elegans sperm carry a histone-based epigenetic memory of both spermatogenesis and oogenesis. A highly parallel strategy for storage of digital information in living cells. Dual-view photoacoustic microscopy for quantitative cell nuclear imaging. A formal model of fuzzy-trace theory: Variations on framing effects and the Allais paradox. The 7q Optimal contrast-enhanced MRI image thresholding for accurate prediction of ventricular tachycardia using ex-vivo high resolution models.

Predicting position along a looping immune response trajectory. Health system measurement: Harnessing machine learning to advance global health. Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Tabula Muris Consortium; Overall coordination; Logistical coordination; Organ collection and processing; Library preparation and sequencing; Computational data analysis; Cell type annotation; Writing group; Supplemental text writing group; Principal investigators.

Longitudinal analysis of biomarker data from a personalized nutrition platform in healthy subjects. Notch2-dependent DC2s mediate splenic germinal center responses. Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons.

Double threat in striatal dopamine signaling. Theoretical analysis of inducer and operator binding for cyclic-AMP receptor protein mutants. Inferring single-trial neural population dynamics using sequential auto-encoders. Single-exposure optical focusing inside scattering media using binarized time-reversed adapted perturbation. Shared understanding of narratives is correlated with shared neural responses. Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells.

Primary Visual Cortices. Accurate classification of BRCA1 variants with saturation genome editing. Inverted repeat structures are associated with essential and highly expressed genes on C.

Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles. RNA, Action through Interactions. Three-dimensional genome structures of single diploid human cells. Joint profiling of chromatin accessibility and gene expression in thousands of single cells. High-speed alignment optimization of digital optical phase conjugation systems based on autocovariance analysis in conjunction with orthonormal rectangular polynomials.

Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia. Feedback-mediated signal conversion promotes viral fitness. Tropomyosin dynamics during cardiac muscle contraction as governed by a multi-well energy landscape. Neural Sensing of Organ Volume. Increased thin filament activation enhances alternans in human chronic atrial fibrillation. Links between environment, diet, and the hunter-gatherer microbiome.

Microbiome: Focus on Causation and Mechanism. Directed evolution of excited state lifetime and brightness in FusionRed using a microfluidic sorter. A maximum likelihood approach to power calculations for stepped wedge designs of binary outcomes.

Atomic insights into the genesis of cellular filaments by globular proteins. Exploring early human brain development with structural and physiological neuroimaging. Escherichia coli translation strategies differ across carbon, nitrogen and phosphorus limitation conditions. Mapping the Genetic Landscape of Human Cells. Enzymatic one-step ring contraction for quinolone biosynthesis. Drosophila species learn dialects through communal living.

Evaluating Public Health Interventions: 8. Causal Inference for Time-Invariant Interventions. GIVE: portable genome browsers for personal websites. Spreading depolarizations trigger caveolindependent endothelial transcytosis. Small near-infrared photochromic protein for photoacoustic multi-contrast imaging and detection of protein interactions in vivo. Multiple robust estimation of marginal structural mean models for unconstrained outcomes. Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action.

Automated in vivo patch-clamp evaluation of extracellular multielectrode array spike recording capability. Attentional fluctuations induce shared variability in macaque primary visual cortex. Dual-axis illumination for virtually augmenting the detection view of optical-resolution photoacoustic microscopy.

An open-source tool for analysis and automatic identification of dendritic spines using machine learning. A method for single-neuron chronic recording from the retina in awake mice. Declining responsiveness to influenza vaccination with progression of human pregnancy. Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure.

Single-breath-hold photoacoustic computed tomography of the breast. Bright quantum dots emitting at? Access of choice-disabled young women in Botswana to government structural support programmes: a cross-sectional study. Light sheet theta microscopy for rapid high-resolution imaging of large biological samples. Quantifying the uncertainty in model parameters using Gaussian process-based Markov chain Monte Carlo in cardiac electrophysiology. Single cell genomics to study DNA and chromosome changes in human gametes and embryos.

Electroencephalographic markers of brain development during sevoflurane anaesthesia in children up to 3 years old. Multiplex assessment of protein variant abundance by massively parallel sequencing. Community-based benchmarking improves spike rate inference from two-photon calcium imaging data. Role of inhibitory control in modulating focal seizure spread.

Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism. Cardiac Optogenetics: Diverse reprogramming codes for neuronal identity. Tsunemoto, Rachel; Lee, Sohyon; Sz? Regulation of seizure-induced MeCP2 Ser phosphorylation in the developing brain. A critical role for nucleoporin Nup in transposon silencing and piRNA biogenesis in Drosophila. Systematic approach for dissecting the molecular mechanisms of transcriptional regulation in bacteria.

Metabolomics and Isotope Tracing. Combinatorial programming of human neuronal progenitors using magnetically-guided stoichiometric mRNA delivery. Development of an optogenetic toolkit for neural circuit dissection in squirrel monkeys. Widespread intronic polyadenylation diversifies immune cell transcriptomes.

A Caenorhabditis elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte gene expression, sperm production and fertility. Single-cell reconstruction of developmental trajectories during zebrafish embryogenesis. Cryo-EM structure of the gasdermin A3 membrane pore.

Bridging barriers: a comparative look at the blood-brain barrier across organisms. Optogenetics and Chemogenetics. Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity.

Holographic imaging and photostimulation of neural activity. Design of a sustainable prepolarizing magnetic resonance imaging system for infant hydrocephalus. Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism. Recent progress in photoacoustic molecular imaging. Mechanisms of cancer resistance in long-lived mammals. Stochastic tuning of gene expression enables cellular adaptation in the absence of pre-existing regulatory circuitry.

Complete biosynthesis of noscapine and halogenated alkaloids in yeast. Simultaneous single-cell profiling of lineages and cell types in the vertebrate brain. Cysteine dioxygenase is essential for mouse sperm osmoadaptation and male fertility.

Interbrain cortical synchronization encodes multiple aspects of social interactions in monkey pairs. Deconstructing the pluripotency gene regulatory network. Reactivation of the Nkx2. Sirtuin activators and inhibitors: Promises, achievements, and challenges.

Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction. The African turquoise killifish: A research organism to study vertebrate aging and diapause. Economic burden of neonatal sepsis in sub-Saharan Africa.

A deep neural network to assess spontaneous pain from mouse facial expressions. The cis-regulatory dynamics of embryonic development at single-cell resolution. The Biosynthesis of Lipooligosaccharide from Bacteroides thetaiotaomicron. Zinc transporters belonging to the Cation Diffusion Facilitator CDF family have complementary roles in transporting zinc out of the cytosol. Relatively slow stochastic gene-state switching in the presence of positive feedback significantly broadens the region of bimodality through stabilizing the uninduced phenotypic state.

Toward a universal decoder of linguistic meaning from brain activation. Neuronal regulation of longevity by staying cool. A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters. Modifications and functional genomics of human transfer RNA. OligoMiner provides a rapid, flexible environment for the design of genome-scale oligonucleotide in situ hybridization probes.

QFMatch: multidimensional flow and mass cytometry samples alignment. Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6. A spatial gradient of bacterial diversity in the human oral cavity shaped by salivary flow. Efficient derivation of stable primed pluripotent embryonic stem cells from bovine blastocysts. Immunology of the Uterine and Vaginal Mucosae. Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence.

Mechanism of ubiquitin transfer promoted by TRAF6. Survival analysis with functions of mismeasured covariate histories: the case of chronic air pollution exposure in relation to mortality in the nurses' health study. Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain.

Simultaneous two-photon imaging and two-photon optogenetics of cortical circuits in three dimensions. Emotion fingerprints or emotion populations? A meta-analytic investigation of autonomic features of emotion categories. Contextual control of skin immunity and inflammation by Corynebacterium.

Regulation of amyloid-? A statistical model for improved membrane protein expression using sequence-derived features. Mitochondrial translation requires folate-dependent tRNA methylation. Skin microbiota-host interactions. Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects. The effect of risk factor misclassification on the partial population attributable risk. Learning situated emotions.

Time-reversed ultrasonically encoded optical focusing through highly scattering ex vivo human cataractous lenses. Paternal chromosome loss and metabolic crisis contribute to hybrid inviability in Xenopus.

Growth factor delivery strategies for rotator cuff repair and regeneration. Patient-derived xenografts of low-grade B-cell lymphomas demonstrate roles of the tumor microenvironment. ERAASR: an algorithm for removing electrical stimulation artifacts from multielectrode array recordings.

The Emergence and Collapse of Knowledge Boundaries. High-speed single-shot optical focusing through dynamic scattering media with full-phase wavefront shaping.

Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells. Prevalence estimation when disease status is verified only among test positives: Applications in HIV screening programs. Facilitators and barriers to healthy eating in a worksite cafeteria: a qualitative study from Nepal.

Nodal patterning without Lefty inhibitory feedback is functional but fragile. Focusing light through scattering media by polarization modulation based generalized digital optical phase conjugation.

Mesh electronics: a new paradigm for tissue-like brain probes. Multimodal profiling of single-cell morphology, electrophysiology, and gene expression using Patch-seq. Dietary interventions to prevent and manage diabetes in worksite settings: a meta-analysis.

A craniofacial-specific monosynaptic circuit enables heightened affective pain. Temporally precise single-cell-resolution optogenetics. Label-free photoacoustic tomography of whole mouse brain structures ex vivo. Protein localization screening in vivo reveals novel regulators of multiciliated cell development and function. Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition.

BAD knockout provides metabolic seizure resistance in a genetic model of epilepsy with sudden unexplained death in epilepsy. A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites. Evaluating Public Health Interventions: 7. IL is a crucial determinant of cardiovascular fibrosis. Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance.

Preconceptual Zika virus asymptomatic infection protects against secondary prenatal infection. Chromatin accessibility dynamics reveal novel functional enhancers in C.

Nematocytes: Discovery and characterization of a novel anculeate hemocyte in Drosophila falleni and Drosophila phalerata. Augmenting intracortical brain-machine interface with neurally driven error detectors.

Label-free automated three-dimensional imaging of whole organs by microtomy-assisted photoacoustic microscopy. Nicotinamide mononucleotide NMN supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise. Ultrasensitive optical imaging with lanthanide lumiphores. Facephenes and rainbows: Causal evidence for functional and anatomical specificity of face and color processing in the human brain.

Building multidisciplinary research. A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes. Small molecule alteration of RNA sequence in cells and animals. Regulation of reproduction and longevity by nutrient-sensing pathways. Perceiving social interactions in the posterior superior temporal sulcus. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Whispering-gallery-mode emission from biological luminescent protein microcavity assemblies. Nonlatching positive feedback enables robust bimodality by decoupling expression noise from the mean. Glucose feeds the TCA cycle via circulating lactate. Identifying direct contacts between protein complex subunits from their conditional dependence in proteomics datasets. High-throughput screens using photo-highlighting discover BMP signaling in mitochondrial lipid oxidation.

In vivo programming of endogenous antibodies via oral administration of adaptor ligands. Do Gametes Woo? Evidence for Their Nonrandom Union at Fertilization. Slowing Down Aging.

The effect of antibiotics on protein diffusion in the Escherichia coli cytoplasmic membrane. Cardiomyoblasts Contribute to Cardiomyogenesis in the Neonatal Heart. Motionless volumetric photoacoustic microscopy with spatially invariant resolution.

MUC1 Tn immunity. Sensitivity of reentrant driver localization to electrophysiological parameter variability in image-based computational models of persistent atrial fibrillation sustained by a fibrotic substrate. Boosting the down-shifting luminescence of rare-earth nanocrystals for biological imaging beyond ?

Musings on mechanism: quest for a quark theory of proteins? From structure to function, how bioinformatics help to reveal functions of our genomes. Toward a conceptual framework for early brain and behavior development in autism. PD-L1 is an activation-independent marker of brown adipocytes. Laminar differences in decision-related neural activity in dorsal premotor cortex. CbtA toxin of Escherichia coli inhibits cell division and cell elongation via direct and independent interactions with FtsZ and MreB.

Estimation and Inference for the Mediation Proportion. Metabolic crosstalk regulates Porphyromonas gingivalis colonization and virulence during oral polymicrobial infection.

Improving membrane protein expression by optimizing integration efficiency. SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis. Variant Interpretation: Functional Assays to the Rescue. Localized CD47 blockade enhances immunotherapy for murine melanoma. PhenoGraph and viSNE facilitate the identification of abnormal T-cell populations in routine clinical flow cytometric data.

Regulation by 3'-Untranslated Regions. What is changing when: Decoding visual information in movies from human intracranial recordings. Comprehensive single-cell transcriptional profiling of a multicellular organism. Sonofragmentation of Ultrathin 1D Nanomaterials. Molecular signatures of longevity: Insights from cross-species comparative studies. Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood.

Electrophysiological properties of basal forebrain cholinergic neurons identified by genetic and optogenetic tagging. Leveraging neural dynamics to extend functional lifetime of brain-machine interfaces. Tissue-specific emergence of regulatory and intraepithelial T cells from a clonal T cell precursor. The checkpoint for agonist selection precedes conventional selection in human thymus. Space- and intensity-constrained reconstruction for compressed ultrafast photography.

Multi-scale approaches for high-speed imaging and analysis of large neural populations. The evolution of the host microbiome as an ecosystem on a leash. A molecular signature for anastasis, recovery from the brink of apoptotic cell death. Single stranded adeno-associated virus achieves efficient gene transfer to anterior segment in the mouse eye.

Targeted DNA methylation in human cells using engineered dCas9-methyltransferases. New insights on the regulation of the adenine nucleotide pool of erythrocytes in mouse models. Multiview Hilbert transformation in full-ring transducer array-based photoacoustic computed tomography. Dynamic structure of locomotor behavior in walking fruit flies. Identification of a hybrid myocardial zone in the mammalian heart after birth.

Epigenetic plasticity and the hallmarks of cancer. Gene expression signatures of human cell and tissue longevity. Nanoscale imaging of clinical specimens using pathology-optimized expansion microscopy.

Efficacy and safety of voretigene neparvovec AAV2-hRPE65v2 in patients with RPEmediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial. Translation fidelity coevolves with longevity. Quantitative real-time imaging of glutathione. Jiang, Xiqian; Chen, Jianwei; Baji? A novel mechanism for mechanosensory-based rheotaxis in larval zebrafish. Novel mobility test to assess functional vision in patients with inherited retinal dystrophies.

Self-consistent theory of transcriptional control in complex regulatory architectures. Spectral reading of optical resonance-encoded cells in microfluidics. Metabolic labeling in middle-down proteomics allows for investigation of the dynamics of the histone code.

Sub-Nyquist sampling boosts targeted light transport through opaque scattering media. Tissue specific requirements for WNT11 in developing outflow tract and dorsal mesenchymal protrusion. Non-model model organisms. Systematic bacterialization of yeast genes identifies a near-universally swappable pathway. Model-based spike sorting with a mixture of drifting t-distributions.

The relationship between cardiac endothelium and fibroblasts: it's complicated. Light in diagnosis, therapy and surgery. An efficient methodology to introduce o- aminomethyl phenyl-boronic acids into peptides: alkylation of secondary amines. Myofilament protein dynamics modulate EAD formation in human hypertrophic cardiomyopathy. High-resolution deep functional imaging of the whole mouse brain by photoacoustic computed tomography in?

A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve.

Live imaging of follicle stimulating hormone receptors in gonads and bones using near infrared II fluorophore. Emotion words: Adding face value. Unconventional Roles of Opsins. Integration of over 9, mass spectrometry experiments builds a global map of human protein complexes. Evaluating Public Health Interventions: 6. Modeling Ratios or Differences?

Let the Data Tell Us. Engineered Cpf1 variants with altered PAM specificities. Mesoscale-duration activated states gate spiking in response to fast rises in membrane voltage in the awake brain.

Fast label-free multilayered histology-like imaging of human breast cancer by photoacoustic microscopy. A Polecat's View of Patrolling Monocytes. A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging. Whole-brain serial-section electron microscopy in larval zebrafish. Immunological implications of pregnancy-induced microchimerism.

Nucleotide-time alignment for molecular recorders. Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development. Human CTP synthase filament structure reveals the active enzyme conformation.

Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease. Strategies for the acquisition of transcriptional and epigenetic information in single cells. Cell diversity and network dynamics in photosensitive human brain organoids. Microbial metabolites regulate host lipid metabolism through NR5A-Hedgehog signalling. Monocyte differentiation and antigen-presenting functions. Engineering genetic circuit interactions within and between synthetic minimal cells.

Super-multiplex vibrational imaging. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. Iterative expansion microscopy. Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway.

Automated deep-phenotyping of the vertebrate brain. Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication. B Activation. Using personalized computer models to custom-tailor ablation procedures for atrial fibrillation patients: are we there yet? Contractile force generation by 3D hiPSC-derived cardiac tissues is enhanced by rapid establishment of cellular interconnection in matrix with muscle-mimicking stiffness.

Mono-unsaturated fatty acids link H3K4me3 modifiers to C. Bioacoustic-enabled patterning of human iPSC-derived cardiomyocytes into 3D cardiac tissue. Non-overlapping Neural Networks in Hydra vulgaris. In vivo imaging of neural activity. Exosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injection. Harnessing cAMP signaling in musculoskeletal regenerative engineering. High-numerical-aperture cryogenic light microscopy for increased precision of superresolution reconstructions.

Potential energy landscapes identify the information-theoretic nature of the epigenome. Internal valence modulates the speed of object recognition. Cardiac Regeneration: Lessons From Development. Imaging and Optically Manipulating Neuronal Ensembles. Discovering sparse transcription factor codes for cell states and state transitions during development. Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states.

Mating and male pheromone kill Caenorhabditis males through distinct mechanisms. Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution. Non-enzymatic molecular damage as a prototypic driver of aging. Determinants of Adiposity Rebound Timing in Children.

Dry coupling for whole-body small-animal photoacoustic computed tomography. Enzyme-Catalyzed Intramolecular Enantioselective Hydroalkoxylation. Measuring speaker-listener neural coupling with functional near infrared spectroscopy. Age-associated molecular changes are deleterious and may modulate life span through diet.

Optical control of cell signaling by single-chain photoswitchable kinases. Myeloid cells pave the way for lymphatic system development and maintenance.

High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells. Qualitative analysis of repaired filtering blebs with anterior segment-optical coherence tomography.

Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c. A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear. Massively multiplex single-cell Hi-C. Submillimeter diffusion tensor imaging and late gadolinium enhancement cardiovascular magnetic resonance of chronic myocardial infarction.

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance. Single-shot real-time video recording of a photonic Mach cone induced by a scattered light pulse.

Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis. Holliday junction trap shows how cells use recombination and a junction-guardian role of RecQ helicase. A bacterial global regulator forms a prion. Function and origin of mistranslation in distinct cellular contexts.

Organization of high-level visual cortex in human infants. CD36 deficiency impairs the small intestinal barrier and induces subclinical inflammation in mice. Back to the Basics: Cnidarians Start to Fire. Ultrastructural evidence for impaired mitochondrial fission in the aged rhesus monkey dorsolateral prefrontal cortex. Developmental broadening of inhibitory sensory maps. Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors. Modelling methodology of atrial fibrosis affects rotor dynamics and electrograms.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. Towards personalized computational modelling of the fibrotic substrate for atrial arrhythmia.

A feasibility study of arrhythmia risk prediction in patients with myocardial infarction and preserved ejection fraction. Piezo2 senses airway stretch and mediates lung inflation-induced apnoea.

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